Toxicity Profile of Pyrrolizidine Alkaloid-Containing Medicinal Plants: Emphasis on Senecio Species
نویسندگان
چکیده
Pyrrolizidine alkaloids (PAs) are found in various plant genera worldwide. Poisoning by PA-containing plants is usually accidental, by the ingestion of grain inadvertently contaminated with seeds of pyrrolizidine-containing weeds, or the consumption of herbal or bush tea, or when taken as herbal infusions for medicinal purposes. In this paper the toxicity of PA-containing plants, with emphasis on Senecio spp. is reviewed. Although the toxicity of Senecio has been documented in numerous case reports, the mechanism of toxicity is not fully known. Elucidating the factors involved in herbal remedies-induced toxicity has medical significance. Currently, there is no antidote for naturalsubstances that induce liver damage. It is important to understand the need for monitoring the use of herbal medicine in order to optimize herbal/traditional medicine use and maximize the clinical and economical benefits. It is also necessary to enhance communication between scientists and physicians of all disciplines involved in complementary alternative medicine and clinical toxicology. _____________________________________________________________________________________________________________
منابع مشابه
Pyrrolizidine Alkaloid– Containing Toxic Plants (<i>Senecio, Crotalaria, Cynoglossum, Amsinckia, Heliotropium, </i> and <i>Echium</i> spp.)
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